There is currently no definitive answer to the question of exactly how psychedelics interact with the brain to alleviate symptoms like depression and anxiety.
Similar to traditional antidepressant drugs, psychedelics act on the neurotransmitter system for serotonin, which is known as the “happy chemical” due to its role in regulating well-being and happiness. It is thought that the interaction with serotonin could be one explanation for the relationship between psychedelics and mood.
Compared to traditional medications, psychedelics have fewer unwanted side effects. It is speculated that this could, in part, be because they are not consumed daily.[1]
It’s also worth noting that psychedelics act more quickly than pharmaceuticals, which take time to build in the system. With microdosing, the positive impact may be felt immediately, even after just one administration.[2]
Some speculate that the effectiveness of microdosing could also be due to the placebo effect. With YouTubers, Redditors, and even Silicon Valley entrepreneurs proclaiming microdosing’s benefits, users have strong expectations that hallucinogens will give them the results they want. [3]
Interestingly, microdosing appears to be most effective when users have a clear intention for doing so.[4] Those who set clear goals of what they want to achieve or what symptoms they want to alleviate seem to notice the best results.[5]